Macroporous resin adsorption separation technology is a novel purification process that uses special adsorbents to selectively adsorb the effective components from concentrated traditional Chinese medicine (TCM) compound extracts, removing ineffective components. It can solve practical problems faced in TCM production, such as large dosages, product hygroscopicity, and heavy metal residues. The refined product obtained after macroporous resin adsorption treatment has a high concentration of active ingredients, few impurities, and an extraction yield of only 2%-5% of the original drug. It effectively removes hygroscopic components, which is beneficial for the production of various TCM dosage forms and enhances product stability. It also effectively removes heavy metals. The extract obtained by macroporous resin adsorption separation is small in volume, non-hygroscopic, and easily formulated into various aesthetically pleasing dosage forms, especially suitable for the production of granules, capsules, and tablets.

▎Equipment Features

1. This equipment is a long, narrow stainless steel column, usable under both negative and positive pressure.

2. Main system components: platform, column, filtration system, process inlets.

3. Column specifications: diameter Ф200~1000mm, height customizable, working pressure ≦0.3Mpa.

4. Upper and lower end flange connection, internal filtration device using stainless steel filter screen or stainless steel water cap.

5. Filtration accuracy: 100-400 mesh.

6. Material: 304/316L stainless steel.

7. The column is equipped with resin inlet/outlet, sight glass, and liquid inlet/outlet ports.

8. Operation generally consists of three main steps: sample loading, elution, and regeneration.

9. Applications of chromatography columns: Suitable for the purification and separation of materials in traditional Chinese medicine, food, and chemical industries. Based on the different affinities between the plant's active ingredients and the resin in the chromatography column, different categories or different components are separated in layers to obtain the active ingredients. It is a very important and precise method for preparing high-efficacy, small-dose traditional Chinese medicines.